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STEP UP, the phase 3b trial (a large human study) that compared the two doses in 1,407 adults living with obesity, reported these sensations in: 1 22.9% of people on Wegovy 7.2 mg 6.0% of people on Wegovy 2.4 mg 0.5% of people on a placebo (1 participant out of 201) That’s close to four times as many people on 7.2 mg as on 2.4 mg, which is why this side effect has become associated with the higher dose
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These processes impact the diabetes phenotype and subsequently contribute to the progression of both microvascular and macrovascular complications [22]
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