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Moreover, phenformin, at non-cytotoxic concentrations, had also an indirect anti-cancer effect through modulation of the chemokine milieu within the thyroid tumor microenvironment (inhibition of CXCL8 secretion) ( in vivo ( In 2011, a study revealed that the administration of phenformin in combination with 2-deoxyglucose can prevent the development of lactic acidosis, reducing toxicity
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