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To view or add a comment, sign in Nitroglycerin (NTG) Class: • Organic nitrate • Vasodilator Mechanism of Action • Converted to nitric oxide (NO) in vascular smooth muscle • Activates guanylate cyclase → ↑ cGMP → smooth muscle relaxation • Effects: • Venodilation → ↓ preload (reduces myocardial oxygen demand) • Coronary artery dilation → ↑ oxygen supply to ischemic myocardium • Arterial dilation at higher doses → ↓ afterload Indications • Acute angina pectoris (chest pain) • Chronic stable angina (prophylaxis) • Acute coronary syndromes (adjunct therapy) • Heart failure with acute pulmonary edema Routes of Administration • Sublingual tablets / spray: Rapid relief of acute angina • Oral / extended-release tablets: Long-term prophylaxis • Transdermal patch / ointment: Continuous delivery for chronic angina • IV infusion: Severe heart failure, acute MI, hypertensive emergencies Dosage (Typical) • Sublingual: 0.3–0.6 mg every 5 minutes as needed, max 3 doses in 15 min • Transdermal patch: 0.1–0.8 mg/hr (patch-free interval recommended to prevent tolerance) • IV infusion: Start 5 mcg/min, titrate to effect Adverse Effects • Headache (most common) • Hypotension → dizziness, syncope • Flushing, tachycardia (reflex) • Nausea • Methemoglobinemia (rare, high doses or IV) Precautions / Contraindications • Avoid with PDE-5 inhibitors (sildenafil, tadalafil) → severe hypotension • Use cautiously in hypotension, severe anemia, increased intracranial pressure • Tolerance develops with continuous exposure → use intermittent dosing or nitrate-free interval • Rapid-acting vasodilator for acute angina → sublingual route preferred • Main side effect: headache, hypotension • Avoid nitrates with sildenafil → life-threatening hypotension • Reduces preload (primary) and afterload (secondary) To view or add a comment, sign in ⚠️ Potassium in DKA: Treat It Right or Risk the Heart ⚠️ In Diabetic Ketoacidosis (DKA), potassium management is just as critical as insulin therapy

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somnifera root extract and leaf extract on blood glucose levels were more pronounced than those of glibenclamide (90)