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Based on findings originally obtained in studies of the group GPCR for parathyroid hormone (PTH), 67 a two-domain model for GLP-1R activation exists in which the α-helical C-terminus of GLP-1 (7–36)amide interacts with the receptor's N-terminal domain, while the N-terminus of GLP-1(7–36)amide interacts with ECL-1 and ECL-2 of the GLP-1R
