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For women with lipoedema who already commonly present with digestive issues, histamine intolerance, MCAS, reflux associated with hiatus hernia, or who wear compression garments that fit around the abdomen, which can place upward pressure on the stomach, this cascade of gastrointestinal complications is a very real and underacknowledged risk that needs consideration before starting these medications

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Bottom line: While you can take ibuprofen while on Zepbound®, doing so mindfully—by staying hydrated, taking it with food, and being aware of delayed absorption—is the best way to ensure your comfort and safety